Clinical effects of steroid in the perioperative management of patients undergoing extensive esophagectomy

摘要

We investigated clinical effects of steroid during perioperative management of 40 patients undergoing extensive radical surgery for esophageal cancer. Methylprednisolone 500 mg was administered in 20 patients preoperatively (the steroid group). The non-steroid group received no steroid. Clinical parameters checked were pre- and postoperative changes of P/F ratio, fluid balance and postoperative epidural analgesia in the two groups. The steroid group had significantly more optimal P/F ratio postoperatively. Fluid balance was significantly more favorable, and postoperative period was significantly less painful in the steroid group. We assumed that steroid had prevented enhancement of vascular permeability and also had suppressed secretion of inflammatory mediators. We conclude that preoperative administration of steroid is beneficial for the perioperative management of patients undergoing extensive surgery.