難消化性デキス卜リン含有茶飲料摂取による 食後血中中性脂肪上昇抑制一無作為化プラセボ対照二重盲検クロス才ーバ一 試験一

摘要

Objective The aim of this study was to evaluate the effectiveness of indigestible dextrin-containing tea beverage on the postprandial increase in serum triglyceride level in subjects with moderately high fasting serum triglyceride levels. Methods Volunteers (79 subjects) with their fasting serum triglyceride levels of 120—199 mg/ dL were enrolled in a randomized, placebo-controlled, double-blind, crossover study. Subjects ingested a high-fat meal (44.3 g fat) together with either a test beverage containing 5 g (as dietary fiber) of indigestible dextrin or a placebo beverage without indigestible dextrin. Serum lipids were determined before and 2, 3， 4， and 6 hours after the high-fat meal ingestion. Results When the subjects ingested test beverage, postprandial increases in the levels of serum triglyceride and remnant-like lipoprotein particle cholesterol (RLP-cholesterol) were low compared to those when the subjects ingested placebo beverage. The area under the curve (AUC) for serum triglyceride levels was 1504+478 mg ? h/dL for test beverage and 1593 + 509 mg ? h/dL for placebo; P=0.044 and the AUC for serum RLP—cholesterol was 83.8 ±26.8 mg ? h/dL for test beverage and 89.6+29.5 mg ? h/dL for placebo; P=0.038. Conclusions The ingestion of indigestible dextrin-containing tea beverage suppresses the increase in the postprandial serum triglyceride and remnant-like lipoprotein particle cholesterol levels in subjects with moderately high fasting serum triglyceride levels.