A route to new galactosyl peptides: application to the synthesis of a galactosyl pentapeptide analogue of leu-enkephalin

摘要

The syntheses of a new galactosyl alpha-amino acid building block and modified peptides including this moiety are described.The versatility of the method is illustrated by the preparation of a galactosyl pentapeptide analogue of Leu-enkephalin.Conformational studies of dipeptide models in the galactose series show an intramolecular hydrogen bond interaction between the backbone and the galactosyl side chain of the models.