The immunomodulating activity of a transfer-factor preparation transflavin, specific to tick-borne encephalitis virus

摘要

Transflavin, a tranfer-factor preparation specific to tick-borne encephalitis virus, was experimentally shown to possess immunomodulating action, The immunomodulating action of this preparation could be observed in a dose of 1 D (1 D being equivalent to 5 X 10~8 lymphocytes), which was manifested by an increase in the phagocytic activity of neutrophils and macrophages, a rise in the amount of T-lymphocytes, an increase in rosette formation, the number of antibody-forming cells, increased proliferation on T- and, to a lesser extent, B-cell mitogens, the restoration of the T-dependent expression of lymphocyte receptors, inhibited by trypsin. Transflavin in doses of 0,1 and 10 D suppressed primary immune response. The probable mechanisms of the immunomodulating action of the Transflavin under study is discussed