The basal secretion of appetite regulating hormones in Tsumura, Suzuki, Obese Diabetes male mice and the effects of pair-feedingon those secretion

摘要

In recent years, obesity has been increasingly cited as a major health issue in developed countries. Obesity or metabolic syndrome is considered to be a major risk factor for chronic diseases such as hypertension, cardiovascular disease and type II diabetes, and researches of these areas have been increasing. Selecting animal models to the study of obesity is important, and the most characteristic examples of obese models are ob/ob and db/db mice with monogenic background. These mice develop obesitydue to mutations in leptin (ob/ob) or leptin receptors (db/db) gene. On the other hand, Tsumura Suzuki Obese Diabetes (TSOD) mice were newly established as multi-gene obese diabetes model, which showed hyperphagia, hyperglycemia, hyperinsulinemia and insulin resistance. TSOD mice have been reported that the abnormality of insulin secretion, but another endocrine problem in TSOD mice is not clear. In the present study, we examined the basal secretion of feeding-related hormones, leptin, peptide YY (PYY)and glucagon-like peptide 1 (GLP-1) in TSOD mice. In addition, leptin was injected to TSOD mice to examine the leptin resistance, and the effects of pair-feeding on insulin and leptin secretions in TSOD mice were also investigated.