Studies on effect of rCalFN- y on the propofol-isoflurane anesthesia-induced suppression of anti-tumor immunity in dogs

摘要

Recently, aging of companion animals such as dogs and cats has progressed as well as human, and the clinical cases of tumors have dramatically increased. It is well known that general anesthesia is essential in order to perform the bioimaging diagnosis using MRI, CT etc., the surgical operation or radiation therapy to the case suffered from the tumor. In human medicine, immunity ability decreases by adding the surgical stress which includes anesthesia and an operation to the case suffered from the tumor, transition and the rate of recurrence of a tumor after anesthesia or postoperative will increase (Vallejo et al.). Moreover, it has also been reported that the lymphocyte apoptosis of a dog is promoted by general anesthesia and the decrease of lymphocyte count reduction and the immunity ability accompanying it takes place (Yamada et al.). Therefore, the influence of general anesthesia to antitumor immunity in dogs with the tumor has not been clarified yet, although the decrease in immune ability bygeneral anesthesia is common in human and dogs. In this research, the influence of the propofol-isoflurane anesthesia, which is popular as general anesthesia in dogs, on antitumor immunity was examined in order to establish the recipe which prevents the fall of antitumor immunity ability.