The distribution of fasting and non-fasting serum triglyceride levels in Japanese population.

摘要

In recent years, accumulating evidence shows that non-fasting serum triglycerides (TG) are important marker for assessing the risk of cardiovascular disease [1-4]. Several clinical studies have shown that delayed elimination of postprandial TG-rich lipoprotein as well as higher TG levels is associated with coronary artery disease (CAD) [5,6]. It has been reported that the presence of CAD is associated with higher postprandial TG concentrations in plasma compared with healthy controls, even after correction for higher levels of fasting TG in CAD group [6-8]. To date, much of the knowledge about the relationship between lipid and lipoprotein metabolism and the development of atherosclerosis and cardiovascular disease is based on measurements in the fasting state. However, human spends their majority of time in a non-fasting state.