Nonfasting serum triglycerides and risk of ischemic heart disease among Japanese men and women

摘要

To examine the relation of triglycerides with ischemic heart disease (IHD) among populations with low mean total cholesterol, we conducted a 16-year prospective study of 11,068 Japanese aged 40-69 (4452 men and 6616 women with mean total cholesterol=4 73 and 5.03 mmol/ 1, respectively), initially free of IHD or stroke.We documented 236 IHD events comprising 133 tnyocardial infarctions, 68 angina pectoris and 44 sudden cardiac deaths Median values of serum triglycerides were higher among IHD incident cases than among controls in each of subgroups of time since last meal <2, 2, 3-7 and 8 h or more. Median difference was particularly large in the subgroup of 3-7 h since last meal (0 90 mmol/1 for men and 0 75 mmol/1 for women). The IHD incidence was greater in a dose-response manner across increasing quartiles of nonfasting triglycerides for both sexes. The multivariate relative risk of'CHD adjusting for coronary risk factors and time since last meal was 2.81 (95% CI, 1.56-5.05) for men and 2,76 (1 34-5.68) for women. The multivariate relative risk associated with 1 mmol/1 greater triglycerides was 1 29 (1,09-1,53) for men and 1,42 (1.15-1.75) for women. The trend was similar for myocardial infarction, angina pectoris and sudden cardiac death. The relation of triglycerides with IHD was not influenced materially by total cholesterol levels or in a subsample analysis (51% of total sample) by HDL cholesterol levels. Nonfasting serum triglycerides predict the incidence of IHD among Japanese men and women, who possess low mean values of total cholesterol.