Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(epeislon-caprolactone) and PEGylated Polyphosphoester

摘要

A novel biodegradable amphiphilic brush-coil block copolymer consisting of poly(epsilon-caprolactone) and PEGylated polyphosphoester was synthesized by ring opening polymerization.The composition and structure of the copolymer were characterized by ~1H NMR,~(13)C NMR,and FT-IR,and the molecular weight and molecular weight distribution were analyzed by gel permeation chromatograph (GPC) measurements to confirm the diblock structure.These amphiphilic copolymers formed micellar structures in water,and the critical micelle concentrations (CMCs) were around 10~(-3) mg/mL,which was determined using pyrene as a fluorescence probe.Transmission electron microscopy (TEM) images showed that the micelles took an approximately spherical shape with core-shell structure,which was further demonstrated by laser light scattering (LLS) technique.The degradation behavior of the polymeric micelle was also investigated in the presence of Pseudomonas lipase and characterized by GPC measurement.Such polymer micelles from brush-coil block copolymers are expected to have wide utility in the field of drug delivery.