ARGINASE II AUGMENTS ADRENERGIC VASOCONSTRICTION VIA A BETA-ADRENERGIC, NITRIC OXIDE INDEPENDENT PATHWAY: EVIDENCE FROM THE ARGINASE H KNOCKOUT MOUSE

摘要

Background: Arginase, which shares the common substrate L-argjnine with nitric oxide synthase (NOS), is upregulated in hypertension and other states of endothelial dysfunction4'5. We have demonstrated that non-specific arginase inhibition prevents tolerance to acetylcholine-elicited relaxation in the rat isolated aorta. There are 2 isoforms of arginase, type I and II. In the current study we investigate the role of arginase isoform type II on vascular responses as a potential mechanism by which arginase influences blood pressure