Relationship between age and intraocular pressure: the Blue MountainsEye Study.

摘要

This study aimed to assess the influence of age on intraocular pressure(IOP) in a general population. The Blue Mountains Eye Study assessed3654 residents aged 49+ years during 1992-1994.Intraocular pressure was measured using Goldmann applanation tonometry.Subjects with glaucoma, those currently on glaucoma medicationsand those with a history of cataract surgery were excluded. TheIOP was reliably measured in 3260 subjects. Mean IOP was 16.0 mmHgwith no significant difference found between men and women (P < 0.89).In univariate analyses, age was positively associated with IOP (P < 0.05).Systolic blood pressure (SBP) was strongly positively associatedwith IOP (P < 0.001). After adjustingfor SBP, there was a trend for IOP to decrease with increasing age(P < 0.051). After further adjustingfor other potential confounders (diabetes, glaucoma family historyand myopia), age was no longer significantly associated with intraocularpressure (P < 0.29). In summary,no evidence was found of an independent age affect on IOP.