Tardive dystonia (TD) is one of the tardive extrapyramidal side effects induced by antipsychotic drugs and is often treatment-resistant. Before atypical antipsychotic drugs became available, many kinds of treatment and drugs were tried to treat TD. However, none of them could sufficiently reduce or ameliorate TD. Recent development of atypical antipsychotics, such as olanzapine, with minimal or no tardive extrapyramidal side effects urged us to try them on our patients with TD.The conclusion of our trial of olanzapine on hospitalized patients are ：1)Eight patients who had been under antipsychotic drug therapies for a long period and developed TD in their cervical and thunk region. 2) Olanzapine was administered in replacement of the conventional antipsychotics which had been given to the patients. 3) Olanzapine alleviated partially and totally tardive dystonia of the patients. The response rate appeared to be 50-100% except one no-response case. 4) We are of the opinion that olanzapine is a drug of choice to prevent and ameliorate TD.
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