PSA change and morbidity of prostate cancer after dietary intervention of low-fat and high-soybean-protein diet for patients with high serum PSA level

摘要

A total of 164 patients with a high serum prostate specific antigen (PSA) level were enrolled in a supervised program of dietary intervention with a low-fat and high-soybean-protein diet. The primary endpoints were the evaluation of PSA change and morbidity of prostate cancer in this population. In the evaluable cases, the average serum PSA level had decreased 0.5 ng/ml after 3 months, 0.3 ng/ml after 6 months, and increased 0.1 ng/ml after 1 year. The change after 3 months was statistically significant (p=0.018, paired t-test). The average PSA doubling time was 444 months. During this study period, 9 of the patients developed prostate cancer. These findings indicate that this dietary intervention method was temporarily able to decrease serum PSA level, and indicates the possibility of prevention of prostate cancer by dietary intervention. However, more detailed analysis is necessary to determine why PSA did not keep decreasing.