Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-, 9-(5-deoxy-beta-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines

摘要

9-(2-Deoxy-beta -D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-beta -D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity. [References: 23]