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High-dose chemotherapy with autologous peripheral blood stem cell transplantation for the treatment of multiple myeloma refractory to conventional chemotherapy

机译:大剂量化疗加自体外周血干细胞移植治疗常规化疗难以治疗的多发性骨髓瘤

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High-dose chemotherapy with autologous peripheral blood stem cell transplantation was administered to five patients with refractory myeloma. To collect peripheral blood stem cells, apheresis was done by administering doxorubicin 40 mg/m2 on the first day, and etoposide 60 mg/m2 on the first, second, and third days, followed by G-CSF administration to harvest cells. The high-dose chemotherapy consisted of melphalan 60 mg/m2 administered for 4 days and infusion of mononuclear cells. No serious side effects were observed during the clinical course. After transplantation, complete or partial responses were achieved. APBSCT is considered to be a useful method because it had an antitumor effect against multiple myeloma that is refractory to conventional chemotherapy, as well as against multiple myeloma that is sensitive to chemotherapy, and it can be safely performed.
机译:对5例难治性骨髓瘤患者进行了大剂量化疗和自体外周血干细胞移植。为了收集外周血干细胞,通过在第一天给予阿霉素40 mg / m2,第一天,第二天和第三天给予依托泊苷60 mg / m2进行血液分离,然后给予G-CSF收获细胞。大剂量化学疗法包括以美法仑60 mg / m2给药4天和输注单核细胞。在临床过程中未观察到严重的副作用。移植后,达到完全或部分反应。 APBSCT被认为是一种有用的方法,因为它对常规化疗难以耐受的多发性骨髓瘤以及对化疗敏感的多发性骨髓瘤具有抗肿瘤作用,并且可以安全地进行。

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