USING DEXTROMETHORPHAN POTENTIOMETRIC MEMBRANE SENSOR IN ANALYSIS OF DEXTROMETHORPHAN H YD ROB ROM IDE IN PHARMACEUTICAL FORMULATION AND URINE; COMPUTATIONAL STUDY

摘要

Dextromethorphan (DXM) is an antitussive (cough suppressant) drug found in many cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychoactive applications. In this study, a potentiometric Uquid membrane sensor for simple and fast determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, DXM-tetraphenylborate complexes were employed as electroactive materials in the membrane.The wide linear range (10~(-6)—10~(-2) M), low detection limit (1 x 10~(-6) M), and fast response time (~5 s) characterize the proposed sensors. Validation of the method shows suitability of the sensors for applycations in the determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine.