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Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension

机译:西尼地平对高血压患者血清尿酸水平和尿中一氧化氮排泄的影响

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摘要

The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid - Creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.
机译:研究了西尼地平对高血压患者血清尿酸水平和尿中一氧化氮排泄的影响。西尼地平治疗前和治疗后2个月(10毫克)采集了16名高血压门诊患者的血液和尿液样本。西尼地平治疗后血清尿酸水平显着降低,而尿酸-肌酐清除率未受影响。西尼地平药物可显着增加尿中一氧化氮的排泄量,尽管氨氯地平没有明显改变。因此,西尼地平具有深厚的降压作用,并可能降低血清尿酸水平并增加肾脏中NO的产生。

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