BACKGROUND AND OBJECTIVES: The aim of this study was to determine the safety and efficacy of hepatic metastasectomy in elderly patients with colorectal liver metastases (CLM). METHODS: A retrospective review of a hepatobiliary database was performed on consecutive patients treated with metastasectomy for CLM. Patients were stratified by age (<70 years old vs. >/=70). Patient and tumor characteristics as well as operative factors were compared, as were morbidity, mortality, and length of stay. Logistic regression and Cox proportional hazards were used to evaluate the association of age and postoperative outcomes. RESULTS: There were 59 elderly (median age 75) and 220 non-elderly (median age 58) patients analyzed over a 13 year period. The Charlson comorbidity index was higher in the elderly group (mean 4.7 vs. 4.4 P = 0.005). Postoperative morbidity and mortality were 52.5 and 0% vs. 48.2 and 4.1% in the elderly and non-elderly groups, respectively (P = 0.56 and P = 0.21). There were no differences in median DFS (21.8 months vs. 28.9 months; P = 0.157) or OS (36 months vs. 47.7 months; P = 0.070) between the elderly and non-elderly groups, respectively. CONCLUSIONS: Age itself does not appear to be a significant contraindication to liver resection, including major hepatectomy, when patients are appropriately selected.
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机译：背景与目的：这项研究的目的是确定老年结直肠肝转移（CLM）患者肝转移的安全性和有效性。方法：回顾性审查肝转移数据库治疗CLM的连续患者。按年龄（<70岁vs。> = 70）对患者进行分层。比较患者和肿瘤的特征以及手术因素，以及发病率，死亡率和住院时间。 Logistic回归和Cox比例风险用于评估年龄与术后结局的关系。结果：在13年期间分析了59例老年患者（中位年龄75岁）和220例非老年患者（中位年龄58岁）。老年人组的查尔森合并症指数更高（平均4.7 vs. 4.4 P = 0.005）。术后发病率和死亡率分别为52.5％和0％，而老年组和非老年组分别为48.2％和4.1％（P = 0.56和P = 0.21）。老年组和非老年组的中位DFS（21.8个月vs.28.9个月; P = 0.157）或OS（36个月vs. 47.7个月; P = 0.070）没有差异。结论：选择合适的患者时，年龄本身似乎并不是肝切除术（包括大肝切除术）的重要禁忌症。
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