首页> 外文期刊>Biophysical Journal >Dynamic deformation and recovery response of red blood cells to a cyclically reversing shear flow: Effects of frequency of cyclically reversing shear flow and shear stress level.
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Dynamic deformation and recovery response of red blood cells to a cyclically reversing shear flow: Effects of frequency of cyclically reversing shear flow and shear stress level.

机译:红细胞对周期性反向剪切流的动态变形和恢复响应:周期性反向剪切流的频率和剪切应力水平的影响。

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Dynamic deformation and recovery responses of red blood cells (RBCs) to a cyclically reversing shear flow generated in a 30-microm clearance, with the peak shear stress of 53, 108, 161, and 274 Pa at the frequency of 1, 2, 3, and 5 Hz, respectively, were studied. The RBCs' time-varying velocity varied after the glass plate velocity without any time lag, whereas the L/W change, where L and W were the major and minor axes of RBCs' ellipsoidal shape, exhibited a rapid increase and gradual decay during the deformation and recovery phase. The time of minimum L/W occurrence lagged behind the zero-velocity time of the glass plate (zero stress), and the delay time normalized to the one-cycle duration remained constant at 8.0%. The elongation of RBCs at zero stress time became larger with the reversing frequency. A simple mechanical model consisting of an elastic linear element during a rapid elongation period and a parallel combination of elements such as a spring and dashpot during the nonlinear recovery phase was suggested. The dynamic response behavior of RBCs under a cyclically reversing shear flow was different from the conventional shape change where a steplike force was applied to and completely released from the RBCs.
机译:红细胞(RBC)对以30微米间隙产生的循环反向剪切流的动态变形和恢复响应,在1,2,3频率下的峰值剪切应力为53、108、161和274 Pa分别研究了5 Hz和5 Hz。 RBC的时变速度随玻璃板速度的变化而变化,没有任何时间滞后,而L / W的变化(其中L和W是RBC的椭圆形的长轴和短轴)在扫描过程中表现出快速的增加和逐渐衰减。变形和恢复阶段。最小L / W发生时间滞后于玻璃板的零速度时间(零应力),并且标准化为一周期持续时间的延迟时间保持在8.0%不变。 RBCs在零应力时间的伸长率随着反转频率的增加而变大。提出了一个简单的机械模型,该模型由快速伸长期间的弹性线性元件和非线性恢复阶段中的弹簧和减震器等元件的平行组合组成。在循环反向剪切流作用下,RBC的动态响应行为与传统的形状变化不同,在常规的形状变化中,逐步的力施加到RBC并从RBC完全释放。

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