Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates

摘要

BackgroundMost amyotrophic lateral sclerosis (ALS) research has focused on mice, but there are distinct differences in the functional neuroanatomy of the corticospinal pathway in primates vs. rodents. A non-human primate model may be more sensitive and more predictive for therapeutic efficacy.