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A HIGH PERFORMANCE COMPUTING APPROACH FOR GENOMIC PREDICTION

机译:遗传预测的高性能计算方法

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摘要

In the field of genomic prediction, genotypes of animals or plants are used to predict either phenotypic properties of new crosses or breeding values (EBVs) for detecting superior parents. Since quantitative traits of importance to breeders are mostlyregulated by a large number of loci (QTL), high-density SNP markers are used to genotype individuals. The most frequently applied SNP arrays for cattle consist of 50,000 SNP markers, but even genotypes with 700,000 SNPs are already available (Cole et al., 2012).Some widely used analysis methods rely on a linear mixed model backbone (Meuwissen et al., 2001), which models the SNP marker effects as random effects, drawn from a normal distribution. The estimates for the marker effects are known as BLUP, which are linear functions of the response variates. It has been shown that when no major genes contribute to the trait, Bayesian predictions and BLUP result in approximately the same prediction accuracy for the EBVs (Hayes et al., 2009; Legarra et al., 2011; Daetwyler et al., 2013).
机译:在基因组预测领域,动植物的基因型可用于预测新杂交的表型特性或用于检测优良亲本的育种值(EBV)。由于对育种者重要的定量性状主要由大量基因座(QTL)调控,因此使用高密度SNP标记对个体进行基因分型。牛最常用的SNP阵列由50,000个SNP标记组成,但即使具有700,000个SNP的基因型也已经可用(Cole等,2012)。一些广泛使用的分析方法依赖于线性混合模型骨架(Meuwissen等, (2001),将SNP标记效应建模为随机效应,从正态分布中得出。标记效果的估计值称为BLUP,它是响应变量的线性函数。研究表明,当没有主要基因参与该性状时,贝叶斯预测和BLUP导致EBV的预测准确性大致相同(Hayes等,2009; Legarra等,2011; Daetwyler等,2013)。 。

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