Effect of selective and non-selective opioids on body temperature in warm- and cold-acclimated rats

摘要

(1) Exposure to ambient temperatures outside the thermoneutral zone modifies energy balance in mammals. (2) This study examined the response of acclimated animals to the administration of non-selective and mu-selective opioid agonists and antagonists on body temperature (T-b). (3) Saline had no effect on T-b. (4) In cold-acclimated animals, naloxone alone decreased T-b while morphine produced a biphasic response. (5) In both warm- and cold-acclimated animals, PL-017 induced hypertherinia. (6) CTAP, had no effect alone and blocked PL-017-induced hyperthermia in both groups of animals. (7) The data shows that acclimation modifies the response of the animals to administration of opioid agonists and antagonists.