A possible mechanism for noradrenaline involvement in the effector responses to cold exposure

摘要

An attempt is made to Summarize the results obtained in our experiments. The data concerning the effect of noradrenaline (NA) on impulse activity of the central and peripheral thermosensors, thermosensitivity in human, the thresholds and the intensity of cold-defense responses. the immune response to antigen under the effect of NA in the cold are reviewed. Based on the summarized data, a scheme for NA involvement in the formation of the effector (cold-defense and immune) responses to cold exposure is suggested. NA affects both the peripheral and central thermosensors. A decrease in the activity and sensitivity of the high frequency skin cold receptors presumably results in a decrease in cold sensation. An increase in the static and dynamic activities of the low frequency cold receptors and a moderate increase in the sensitivity of the neurons of the medial preoptic area of the hypothalamus in the low temperature range may produce a decrease in the threshold and an intensification of the thermoregulatory responses during cooling, as well as a considerable stimulation of the antigen binding function of the immune response during deep cooling, which is suppressed in the absence of NA. Intensification of the effector thermoregulatory and immune responses may also be related to the direct NA effect on the effector organs and tissues.