Role of angiotensin II and its receptors in the development of fever in euhydrated and dehydrated rodents

摘要

(1) There are two types of angiotensin II (ANG II) receptors, AT(1) and AT(2) (2) In this paper, our starting point is our previous finding that hypothalamic AT(2)-receptors modulate PGE-induced fever in a positive fashion. (3) We also present our recent results suggesting that ANG II, acting either peripherally or centrally, or both. contributes to the bacterial endotoxin-induced production of pyrogenic cytokines. (4) Taken together, our data suggest that, in the development of fever, hypothalamic ANG II and AT(2)-receptors may be involved in the final step, and that ANG II also participates in the first step (namely, the bacterial endotoxin-induced synthesis of pyrogenic cytokines).