Enhanced responsiveness to central prostaglandin E or neuropeptide Y in cold-adapted rats

摘要

(1) At their corresponding thermoneutral temperatures, cold-adapted rats, as compared with their non-adapted counterparts, exhibited faster and greater body temperature rises to intracerebroventricular injections of prostaglandin E-1. (2) Similar injections of neuropeptide Y induced significantly greater food intakes in cold-adapted than in nonadapted rats. (3) Cold adaptation is concluded to result in increased sensitivity/responsiveness of central regulatory circuits to various stimuli, including hypersensitivity in the regulation of both body temperature and food intake.