Signaling postprandial hyperthermia: a role for cholecystokinin

摘要

(1) Gastric stretch caused by intragastric injection of calorie-free suspension of BaSO4 activates cholecystokinin (CCK)-A receptors on afferent fibers of the abdominal vagus, resulting in the enhancement of metabolic rate and body temperature, similarly as in postprandial states. (2) Intragastric injection of nutrient suspension acts faster, but this action does not involve the vagus nerve. (3) In transmission of BaSO4-induced abdominal signals, central CCK-B receptor activation plays an important role. (4) Postprandial hypermetabolism and hyperthermia following intragastric injection of calorie-rich nutrient suspension is independent of peripheral or central CCK-ergic mechanisms.