Polymorph formation from solvate desolvation spironolactone forms I and II from the spironolactone-ethanol solvate

摘要

Spironolactone (C24H32O4S) usually crystallizes into an orthorhombic phase, named Form II. Another orthorhombic phase, named Form I, is also known but seems difficult to obtain. Studies of the kinetics of desolvation of the ethanol solvate at room temperature showed that these two forms can be obtained through different mechanisms of desolvation.