Thermal behavior study and decomposition kinetics of amisulpride under non-isothermal and isothermal conditions

摘要

The thermal decomposition of amisulpride was studied by simultaneous thermogravimetry/derivative thermogravimetry (TG/DTG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC). The influence of the heating rate (5, 10, 15 and 20 A degrees C min(-1)) on the TG was verified. For the determination of kinetic parameters from the TG/DTG curves, the following methods were utilized: Arrhenius equation, Coats-Redfern, Horowitz-Metzger, Flynn-Wall-Ozawa and Starink methods. The activation energy obtained was found to be about 108 kJ mol(-1). Drug purity and melting point were determined by Van't Hoff equation. The results were in agreement with the recommended pharmacopoeia.