N,N′-dichloro-bis[2,4,6-trichlorophenyl]urea (CC2) and suspending agents used for the preparation of decontamination formulation against chemical warfare agents: A study of compatibility by thermoanalytical techniques (Conference Paper)

摘要

N,N′-dichloro-bis[2,4,6-trichlorophenyl]urea, known as CC2, is used as a reactive chemical decontaminant of mustard agents. The present study was undertaken to establish the compatibility of CC2 with a number of commonly used suspending agents, using thermoanalytical techniques viz., thermogravimetry (TG) and differential scanning calorimetry (DSC) with the support of Fourier transform infrared spectroscopy (FTIR). The results demonstrated the applicability of TG and DSC as a fast screening tool for analysing the compatibility of drug with excipients at the early stages of a preformulation process. Methylcellulose, hydroxypropylcellulose, and betaine were found to be compatible with CC2.