Fosfomycin concentrations in epithelial lining fluid in weaning piglets.

摘要

Respiratory diseases are one of the most important problems in modern intensive swine production (Gardner and Hird, 1990). These diseases are a common cause of morbidity and mortality in weaning pigs (Gardner and Hird, 1990; Galina et al., 1994; Dos?en et al., 2007). The concentrations of antibiotics in epithelial lining ?uid (ELF) re?ect the antimicrobial activity for extracellular pathogens involved in respiratory diseases (Schentag & Ballow, 1991; Kiem & Schentag, 2008; Ross, 2006). Fosfomycin is a hydrosoluble bactericidal broad-spectrum antibiotic used in Central and South America and various Asian countries. Although fosfomycin showed clinical ef?cacy in the treatment of pulmonary diseases, concentrations in ELF have not still been established in any species. Assuming that the determination of fosfomycin concentration in ELF (biophase) represents the key parameter for establishing ef?cacy of antibiotics, the objective of this work was to characterize the penetrating capacity of fosfomycin in ELF and its relationship with serum concentrations in weaning piglets.