Bioavailability and pharmacokinetics of a novel cephalexin oral paste formulation in fed and fasted dogs

摘要

Cephalexin is a Group 2 (first generation) cephalosporin with excellent activity against many Gram-positive bacteria including beta-lactamase-producing Staphylococcus spp. It appears rapidly absorbed after oral administration in dogs and excreted unchanged in the urine by glomerular filtration and tubular secretion (Prescott, 2006). No veterinary formulation of cephalexin is available in North America, but numerous human oral formulations are used for skin infections in small animal practice. Human parenteral formulations are also available in other markets (Rebuelto et al., 2005), though none is currently available in North America.