Comparative pharmacokinetics of norfloxacin nicotinate in common carp (Cyprinus carpio) and crucian carp (Carassius auratus) after oral administration

摘要

Comparative pharmacokinetics of norfloxacin nicotinate (NFXNT) was investigated in common carp (Cyprinus carpio) and crucian carp (Carassius auratus) after a single oral dose of 10mg/kg body weight (b.w.). Analyses of plasma samples were performed using ultra-performance liquid chromatography (UPLC) with fluorescence detection. After oral dose, plasma concentration-time curves of common carp and crucian carp were best described by a two-compartment open model with first-order absorption. The pharmacokinetic parameters of common carp were similar to those of crucian carp. The distribution half-life (t(1/2)), elimination half-life (t(1/2)), peak concentration (C-max), time-to-peak concentration (T-max), and area under the concentration-time curve (AUC) of common carp were 1.58h, 26.33h, 6069.79g/L, 1.08h, and 103072.36hg/L, respectively, and those corresponding to crucian carp were 1.36h, 26.55h, 9586.06g/L, 0.84h, and 126604.4hg/L, respectively. These studies demonstrated that 10mg NFXNT/kg body weight in common carp and crucian carp following oral dose presented good pharmacokinetic characteristics.