IN VITRO POTENCY OF H OXIMES (HI-6, HL6-7), THE OXIME BI-6, AND CURRENTLY USED OXIMES (PRALIDOXIME,OBIDOXIME, TRIMEDOXIME) TO REACTIVATE NERVE AGENT-INHIBITED RAT BRAIN ACETYLCHOLINESTERASE

摘要

The efficacy of H oximes (HI-6, HLO-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested in vitro. Both H oximes (HI-6, HLO-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase than pralidoxime and obidoxime On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase was low and did not reach the reactivating efficacy of trimedoxime and obidoxime. Thus, none of these compounds can be considered to be a broad-spectrum reactivator of nerve agent-inhibited acetylcholinesterase in spite of high potency to reactivate acetylcholinesterase inhibited by some nerve agents More than one oxime may be necessary for the antidotal treatment of nerve agent-exposed individuals.