HEART-RATE VARIABILITY IN THE APOLIPOPROTEIN E KNOCKOUT TRANSGENIC MOUSE FOLLOWING EXPOSURE TO SEATTLE PARTICULATE MATTER

摘要

Epidemiological studies show that the elderly and/or people with preexisting cardiovascular disease (CVD) are more susceptible to the adverse effects of ambient air pollution Heart-rate variability (HRV) measured through electrocardiogram (ECG) is a sensitive and effective tool for monitoring the adverse effects of paniculate matter (PM) Common HRV parameters used include the standard deviation of the interval between normal beats (SDNN), square root of the mean of the squared differences between normal beats (rMSSD), and distinct high, low, and very low components of frequency Aged apolipopro-tein E knockout transgenic mice, a model of CVD, were implanted with miniaturized ECG telemetry devices and intranasally exposed to saline, 50mng Seattle PM_25 (PM having a mean aerodynamic diameter of <2 5mum), or silica They were monitored for a 1-d baseline prior to and for 4 d following exposure After an initial increase in both heart rate and activity in all groups, there was delayed bradycardia with no change in activity of the animals in the PM- and silica-exposed groups In addition, with PM and silica exposure there was a decrease in HRV parameters, suggesting a decrease in parasympathetic tone, which may lead to cardiac arrhythmia and mortality Seattle PM is a toxic species that modulates the autonomic nervous system in a mouse model of CVD