Procoagulant myeloblast-derived microparticles in AML patients: changes in numbers and thrombin generation potential during chemotherapy.

摘要

Several lines of evidence indicate that cell-derived micro-particles (MPs) are functional entities involved in thrombotic disease [1]. Negatively charged phosphatidylserine in the MP membrane may provide a surface for catalytic complexes such as the tissue factor (TF)/VIIa complex. In addition, MPs may express TF and PSGL-1, the latter being able to bind platelet-and MP-bound P-selectin (CD62P), promoting thrombus development [2,3].