Vitamin D and colorectal cancer: is it time for D3 supplementation in patients with metastatic disease?

摘要

Garland et al. first reported in 1980 a link between vitamin D deficiency and an increased risk of colorectal cancer (CRC) [1]. Garland confirmed the increased risk in geographic locations with low sunlight exposure and in cities with increased risk of rickets, both considered measures of low vitamin D levels [l]. Subsequent studies have suggested a link between vitamin D status, as reflected by 25-OH vitamin D3 level (25-D3), and the risk of CRC. A meta-analysis of studies evaluating the impact of serum 25-D3 and CRC confirmed a statistically significant increased risk of CRC in the vitamin D3-deficient population. This meta-analysis suggested that for every 10 ng/ml increase in 25-D3 levels, there was a 26% reduction in the risk of CRC [2].