Cytoreduction and hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis dissemination from colorectal cancer

摘要

Peritoneal carcinomatosis is an insidious condition that afflicts up to 20% of patients with colorectal cancer annually. Symptoms are related to disease progression in the peritoneal cavity such as bloating and intermittent abdominal pain; diagnostic imaging studies will frequently underestimate the extent of disease. The strategy of operative cytoreduction and hyperthermic intraperitoneal chemotherapy has become increasingly utilized as a therapeutic approach, however, most of the data regarding its efficacy come from single-institution studies. With increased understanding of optimal patient selection and treatment parameters, cytoreduction with hyperthermic intraperitoneal chemotherapy will likely become increasingly accepted as part of an integrated multimodal strategy to treat patients with peritoneal carcinomatosis from colorectal cancer in the future.