Epilepsy is a disorder of the brain that is characterised by an enduring predisposition to generate epileptic seizures. It affects approximately 50 million people in the world and 5/1000 in India. In epilepsy, 3 prognostic groups are generally considered: (1) Spontaneous remission (20-30%) as seen in benign epilepsy with centrotemporal spikes or childhood absences.(2) Remission on anti-epileptic drugs (AEDs) (20 -30%) as occurs in most focal epilepsy and myoclonic juvenile epilepsy syndromes.(3) Persistent seizures under AEDs (30-40%) among which refractory epilepsy (RE) is included.
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