Synthesis of dihydropyrimidinones derivatives by Biginelli reaction in basic medium

摘要

A simple, clean and convenient one-pot method has been, developed for the synthesis of 4-substituted-3,4-dihydropyrimidinone by multicomponent condensation of ethyl acetoacetate, aromatic aldehydes and urea in basic medium in the presence of ethanol under refluxing conditions. The yield of all products is >= 90%. The synthesized compounds have been characterized on the basis of their spectroscopic data.