Synthesis and biological evaluation of some new 4-aryl-1-(4,6-diaryl pyrimidine)-2-azetidinone by conventional and microwave methods and their biological activities

摘要

4-Aryl-1-(4,6-diaryl pyrimidine)-2-azetidinone/4-aryl-3-chloro-1-(4,6-diaryl pyriniidine)-2-azetidinone were prepared by reaction of appropriate 2-(methoxy phenylideneamino)-4-diaryl pyrimidine (Schiff base) and acetyl chloride/ chloroacetylchloride in dimethyl formamide (DMF). The reactions have been carried out by conventional, grindstone technique and microwave irradiation methods. The microwave irradiation method provided higher product yields in a very short period of time as compared to conventional method. All the prepared compounds were characterized by their elemental analysis and spectral (IR, ~1H NMR, Mass) data. The compounds have been evaluated for their spermicidal activity in semen of Holstein Friesian cattle, antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa and antifungal activity against Aspergillus niger, Candida albicaus, Fusarium oxysporum.