Synthesis,characterization and antimicrobial study of substituted bis-[1,3,4]-oxadiazole,bis-[1,3,4]-thiadiazole and bis-[1,2,4]-triazole derivatives

摘要

Series of compounds 1,4-bis-(2-aryl/alkyI-amino-[1,3,4]-oxadiazol-5-yl)-benzenes,1,4-bis-(2-aryI/alkyI-amino-[1,3,4]-thiadiazol-5-yl)-benzenes and 1,4-bis-(3-mercapto-4-aryl/alkyl-[1,2,4]-triazol-5-yl)-benzenes have been synthesized by the oxidative cyclization of di-(N-aryl/alkyl thiocarbamido)terephthalamides using alkaline ethanolic solution of iodine containing potassium iodide,ortho-phosphoric acid and aqueous potassium hydroxide solution respectively.These compounds on acetylation afforded bis-acetyl derivatives,on benzoylation afforded bis-benzoyl derivatives and on reaction with ethyl iodide afforded bis-ethylmercapto derivatives respectively.These compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.