To Die or Not to Die, That's the Question-nd the Answer May Depend on Netrin-1

摘要

Few fields in oncology highlight the excitement towards potential new therapies as vividly as targeted manipulations of signaling pathways, although the clinical outcome of several such therapies has been sobering. Over the past decade, there has been increasing appreciation of the concept of dependence receptors", ie, receptors that induce a specific death signal when their ligand is absent, and another (survival) signal when ligand is bound. The presence of these receptors leads to the cell becoming "dependent" on the presence of the ligand for its survival