Pullout strength of cancellous screws in human femoral heads depends on applied insertion torque, trabecular bone microarchitecture and area! bone mineral density

摘要

For cancellous bone screws, the respective roles of the applied insertion torque (TInsert) and of the quality of the host bone (microarchitecture, areal bone mineral density (aBMD)), in contributing to the mechanical holding strength of the bone screw construct (FPui]oaL), are still unclear. During orthopaedic surgery screws are tightened, typically manually, until adequate compression is attained, depending on surgeons' manual feel. This corresponds to a subjective insertion torque control, and can lead to variable levels of tightening, including screw stripping. The aim of this study, performed on cancellous screws inserted in human femoral heads, was to investigate which, among the measurements of aBMD, bone microarchitecture, and the applied TlnserL, has the strongest correlation with FPunouL.Forty six femoral heads were obtained, over which microarchitectuie and aBMD were evaluated using micro-computed tomography and dual X-ray absorptiometry. Using an automated micro-mechanical test device, a cancellous screw was mseited in the femoral heads at Tinsert set to 55% to 99% of the predicted stripping torque beyond screw head contact, after which FPuiiOut was measured.Fpuiiout exhibited strongest correlations with TInseit (R = 0.88, p<0.001), followed by structure model index (SMI, R=-0.81, p< 0.001), bone volume fraction (BV/TV, R = 0.73, p<0.001) and aBMD (R=0.66, p<0.01). Combinations of TInseri with microarchitectural parameters and/or aBMD did not improve the prediction of FPullout.These results indicate that, for cancellous screws, FPullou, depends most strongly on the applied TInsert> followed by microarchitecture and aBMD of the host bone. In trabecular bone, screw tightening increases the holding strength of the screw-bone construct.