Relationships of Bone Density with Quantitative Ultrasound Parameter in Bovine Cancellous Bone

摘要

The present study aims to investigate the relationships of bone density with quantitative ultrasound (QUS) parameters measured in transmission and backscatter modes in bovine cancellous bone. The speed of sound (SOS), the normalized broadband ultrasound attenuation (nBUA), the broadband ultrasound backscatter (BUB) and the integrated reflection coefficient (IRC) were measured for 35 specimens obtained from proximal ends of seven bovine tibiae. The highest correlation coefficient was observed for SOS (r = 0.75, p < 0.001). Similarly, nBUA was significantly correlated with density (r = 0.71, p < 0.001). In contrast, BUB and IRC were less correlated with density than transmission QUS parameters, but still significantly (r = 0.63 and 0.65, respectively, all p < 0.01). A multiple regression analysis was used to find optimal models for the prediction of apparent bone density by using linear combinations of SOS, nBUA, BUB and IRC, with density as an independent variable and 2, 3 and 4 QUS parameters as dependent variables (r = 0.77 - 0.88, all p < 0.001). The results suggest that the analysis of multiple QUS parameters can contribute to improving the efficacy of QUS procedures in the diagnosis of osteoporosis beyond the established value of SOS and nBUA.