Stuies on the Synthesis, Crystal Structure and Antitumor Activities of Mn(II) Complex Derived form the Desulfurization of N-(p-nitrophenyl)-N'-(methoxycarbonyl) thiourea and o-Phenanthroline

摘要

One new Mn(II) complex, 1, MnL_2 (phen)-2 (L=p-nitrophenylcyanamido-N, phen-o-phenanthroline) has been synthesized and crystallographically characterized .Complex 1 was obtained form the desulfurization and hudrolysis of H_2pmt (H_2pmt=N-(p-nitrophenyl)-N'-(methoxycarbonyl) thiourea) in alkaline media. 1 crystallized in the triclinic space group P-1 with a =11.0320 (3), b=11.7831(4), c=12.9288(4) A; #alpha#=87.3590(10), #beta#=81.7500(10), #gamma#=84.0080(10) deg . Preliminary pharmacological tests showed that complex 1 exhibited definite inhibition activities against human ovary tumor 3A0 and mice P338 in vitro.