Cross-coupling reactions in Cinchona alkaloid chemistry: arylsubstituted and dimeric quinine,quinidine,as well as quincorine and quincoridine derivatives

摘要

Cross-coupling reactions of modified Cinchona alkaloids provide access to a wide variety of novel arylated and dimeric derivatives of quinine and quinidine containing a single an ddouble 1,2-amino alcohol functionality.Sonogashira and Heck reactions allow functionalization of ethynyl an d11-iodovinyl precursors.The role of bystander functionality is investigated.