The synthesis of novel 3', 5'-homocyclic nucleotides as potential anti-HIV agents

摘要

(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H-)-one has been converted into cytosine 2', 3'-dideoxy-3', 5'-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.