Synthetic approaches towards phorbols via the ultra-high-pressure mediated intramolecular Diels-Alder reaction of furans (IMDAF): effect of furan substitution

摘要

Tricyclic structures having the functionality and stereochemistry inherent in phorbol and its analogues may be rapidly constructed by an ultra-high pressure IMDAF reaction. The nature of the 2-thioether substituent on the furan diene is critical for the success of the key cycloaddition reaction.