Stereoselective synthesis of 1'#beta#-2', 3'-dideoxy-2'-bis(ethoxycarbonyl)methyluridine nucleosides by ring opening of cyclopropanated glycals

摘要

Cyclopropanations of glycals followed by Lewis acid-mediated glycosylations with 5-substituted uracils afforded 1'#beta#-2', 3'-dideoxy-2'-bis(ethoxycarbonyl)methyluridine nucleosides in a highly regiospecific and stereoselective manner in good yields.