Synthesis of functional gradient BCP/ZrO_2 bone substitutes using ZrO_2 and BCP nanopowders

摘要

BCP/BCP-ZrO_2/ZrO_2 scaffold with a functionally gradient layered structure (FG BCP/ZrO_2) was fabricated by the polymeric sponge replica method and subsequent dipping process. To enhance the compressive strength and bioactive properties of monolithic ZrO_2 scaffold, ZrO_2 and BCP phases were selected as a main frame and surface layer, respectively. The formation of microcracks was significantly decreased by incorporating an intermediate layer consisting of BCP-Zr02 phase. The thicknesses of the monolithic ZrO_2, BCP-ZrO_2, and BCP layer were around 10-30 ìm, 3-5 ìm, and 2-3 ìm, respectively. The FG BCP/ZrO_2 scaffold showed highly interconnected pores as well as good material properties, which were 68% porosity and 7.2 MPa of compressive strength.